Jeffrey Rothstein, Thomas Philips, and M. A. Pouladi publish paper in Movement Disorders Journal
Philips T, Rothstein JD, Pouladi MA (2014) Preclinical models: needed in translation? A Pro/Con debate. Mov Disord. 2014 Sep 15;29(11):1391-6.
Drs. Rothstein, Petrucelli and Disney et al publish paper in Neuron
Su Z, Zhang Y, Gendron TF, Bauer PO, Chew J, Yang WY, Fostvedt E, Jansen-West K, Belzil VV, Desaro P, Johnston A, Overstreet K, Oh SY, Todd PK, Berry JD, Cudkowicz ME, Boeve BF, Dickson D, Floeter MK, Traynor BJ, Morelli C, Ratti A, Silani V, Rademakers R, Brown RH, Rothstein JD, Boylan KB, Petrucelli L, Disney MD (2014) Discovery of a biomarker and lead small molecules to target r(GGGGCC)-associated defects in c9FTD/ALS. Neuron. 2014 Sep 3;83(5):1043-50.
Jeffrey Rothstein and Thomas Philips publish paper in Experimental Neurology
Philips T, Rothstein JD (2014) Glial cells in amyotrophic lateral sclerosis. Exp Neurol. 2014 May 22. pii: S0014-4886(14)00157-5.
Drs. Rothstein and Sattler et al publish paper in Nature
Haeusler AR, Donnelly CJ, Periz G, Simko EA, Shaw PG, Kim MS, Maragakis NJ, Troncoso JC, Pandey A, Sattler R, Rothstein JD, Wang J (2014) C9orf72 nucleotide repeat structures init iate molecular cascades of disease. Nature. 2014 Mar 13;507(7491):195-200.
RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention.
J. Donnelly, P.W. Zhang, J.T. Pham, A.R. Haeusler, N.A. Mistry, S. Vidensky, E.L. Daley, E.M. Poth, B.N. Hoover, D.M. Fines, N. Maragakis, P.J. Tienari, L. Petrucelli, B.J. Traynor, J. Wang, F. Rigo, C.F Bennett, S. Blackshaw, R. Sattler, J.D. Rothstein (2013) Neuron 80 (2): 415-428.
Increased expression of glutamate transporter GLT-1 in peritumoral tissue associated with prolonged survival and decreases in tumor growth in a rat model of experimental malignant glioma.
Sattler R, Tyler B, Hoover B, Coddington LT, Recinos V, Hwang L, Brem H, Rothstein JD. J Neurosurg. 2013 Oct;119(4):878-86. doi: 10.3171/2013.6.JNS122319. Epub 2013 Aug 2.
Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis.
Kang SH*, Li Y*, Fukaya M, Lorenzini I, Cleveland DW, Ostrow LW, Rothstein JD, and Bergles DE. Nature Neuroscience, 2013 May; 16(5): 571-9. doi: 10.1038/nn.3357. Epub 2013 Mar 31
* These authors contributed equally to the paper.
Oligodendroglia metabolically support axons and contribute to neurodegeneration.
Lee Y, Morrison BM, Li Y, Lengacher S, Farah MH, Hoffman PN, Liu Y, Tsingalia A, Jin L, Zhang PW, Pellerin L, Magistretti PJ, Rothstein JD. Nature. 2012 Jul 26;487(7408):443-8. doi: 10.1038/nature11314.